ENaCt
Tyler AR, Ragbirsingh R, McMonagle CJ, Waddell PG, Heaps SE, Steed JW, Thaw P, Hall MJ, Probert MR. Encapsulated Nanodroplet Crystallization of Organic-Soluble Small Molecules. Chem. 2020, 6(7), 1755-1765.
Crystallisation Techniques
Metherall JP, Carroll RC, Coles SJ, Hall MJ, Probert MR. Advanced crystallisation methods for small organic molecules. Chem. Soc. Rev. 2023, 52(6), 1995-2010.
Applications of ENaCT
Cooper MS, Zhang L, Ibrahim M, Zhang K, Sun X, Röske J, Göhl M, Brönstrup M, Cowell JK, Sauerhering L, Becker S, Vangeel L, Jochmans D, Neyts J, Rox K, Marsh GP, Maple HJ, Hilgenfeld R. Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease. J. Med. Chem. 2022, 65, 19, 13328–13342
Zhu J, Moreno I, Quinn P, Yufit DS, Song L, Young CM, Duan Z, Tyler AR, Waddell PG, Hall MJ, Probert MR, Smith AD, O’Donoghue AC. The Role of the Fused Ring in Bicyclic Triazolium Organocatalysts: Kinetic, X-ray and DFT Insights. J. Org. Chem. 2022, 87(6), 4241–4253
Al Subeh ZY, Waldbusser AL, Raja HA, Pearce CJ, Ho KL, Hall MJ, Probert MR, Oberlies NH, Hematian S. Structural Diversity of Perylenequinones is Driven by their Redox Behavior. J. Org. Chem. 2022, 87(5), 2697–2710
Straker H, McMillian L, Mardiana L, Hebberd G, Watson E, Waddell PG, Probert MR, Hall MJ. Polymorph prediction through structural isomorphism and discovery of a new crystalline form of cannabidiol. Cryst. Eng. Comm. 2023, 25(16), 2479-2484.
High Pressure Crystallography
Taylor CR, Mulvee MT, Perenyi DS, Probert MR, Day GM, Steed JW. Minimizing Polymorphic Risk through Cooperative Computational and Experimental Exploration. J. Am. Chem. Soc. 2020, 142(39), 16668–16680
